Bile Acids
Bile acids (BAs) are a class of important molecules synthesized by the liver using cholesterol as a raw material and are the main component of bile. Their core physiological function is to act as "emulsifiers" to promote the digestion and absorption of fats and fat-soluble vitamins in the intestines. In addition, bile acids are also crucial signaling molecules. By activating receptors such as farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5), they extensively regulate glucose, lipid, and energy metabolism in the body, maintaining metabolic homeostasis in the liver and the whole body. After bile acids secreted by the liver enter the intestines, most of them are reabsorbed back into the liver, forming an "enterohepatic circulation". Their metabolism is closely related to the intestinal flora, which transforms them into secondary bile acids, together forming a complex bile acid pool. When the enterohepatic circulation or flora balance is disrupted, bile acid metabolic disorders become a core link in many diseases, such as cholestatic liver disease, non-alcoholic fatty liver disease, and gallstones. Therefore, detecting the bile acid profile has become an important window for diagnosing related diseases and evaluating health status.
Reagent Kit Information
Detection Method: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reagent Kit Specifications: 96 tests/kit, 192 tests/kit
Product Advantages: Detect multiple bile acids simultaneously, providing more comprehensive information for diagnosis and efficacy monitoring. Sample processing is simple, and the throughput is high. Adopting Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) as the analytical detection technology, it has high specificity and sensitivity, and the detection results are more accurate.
Clinical Significance
1、Significant Individual Differences: Bile acid metabolism is affected by multiple factors such as genes, diet, and intestinal flora, resulting in large individual differences, and the effect of universal schemes varies.
2、Monitoring of Treatment Response: For example, when ursodeoxycholic acid (UDCA) is used to treat primary biliary cholangitis (PBC), it is necessary to assess whether a "biochemical response" is achieved to avoid ineffective treatment.
3、Need for Dose Optimization: For drugs such as obeticholic acid (OCA), the dose needs to be precisely controlled to avoid side effects such as pruritus. Therapeutic Drug Monitoring (TDM) can realize individualized dose adjustment.
4、Disease Diagnosis and Classification: Specific bile acid profiles (such as the CDCA/CA ratio) are helpful for the diagnosis and classification of rare diseases such as bile acid synthesis disorders.
Applicable Populations
1、Patients with Primary Biliary Cholangitis (PBC): Assessment of biochemical response after UDCA or OCA treatment.
2、Patients with Primary Sclerosing Cholangitis (PSC): Monitoring of disease progression and evaluation of new drug efficacy.
3、Patients with Cholestatic Liver Disease: Etiological differentiation and severity assessment.
4、Children with Congenital Bile Acid Synthesis Disorders: Diagnosis, classification, and monitoring of replacement therapy.
5、Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)/Metabolic Syndrome: Assessment of the role of bile acid metabolic disorders in the disease.
6、Those Undergoing Intestinal Surgery (e.g., Bariatric Surgery): Monitoring of changes in bile acid metabolism and its impact on metabolism.
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