Reagent Kit Information

Detection Method: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) 

Reagent Kit Specifications: 96 tests/kit, 192 tests/kit 

Product Advantages: Simple pretreatment, comprehensive determination of varieties, provision of a full set of standard curve quality control, no need for on-site high-concentration dilution.

Clinical Significance

1、Significant Individual Differences: Different patients (in terms of age, body weight, liver and kidney function, metabolic status) have remarkable differences in amino acid requirements and metabolic capacity. A "one-size-fits-all" formula may be ineffective or even harmful. 

2、Narrow Therapeutic Window: Excess of certain amino acids can cause toxicity (e.g., phenylalanine in phenylketonuria), while deficiency fails to meet therapeutic needs (e.g., arginine for urea cycle disorders). 

3、Difficulty in Efficacy Evaluation: The improvement of clinical symptoms is delayed, and blood drug concentration is a more immediate and objective efficacy indicator. 

4、Avoid Complications: Precise regulation can prevent complications such as metabolic acidosis, hyperammonemia, and liver and kidney function damage.

Applicable Populations

1、Children with Inborn Errors of Metabolism (IEM): Such as phenylketonuria (PKU), maple syrup urine disease (MSUD), tyrosinemia, urea cycle disorders, etc., who need lifelong monitoring and diet/drug management. 

2、Critically Ill Patients and Surgical Patients: Patients on long-term parenteral nutrition (PN) support need to optimize amino acid formulations to avoid overfeeding or undernutrition. 

3、Patients with Impaired Liver or Kidney Function: Liver/kidney diseases lead to abnormal amino acid metabolism, requiring special proportioning (e.g., branched-chain amino acids, BCAA). 

4、Tumor Patients: In a hypermetabolic state, nutritional support regimens need precise adjustment. Other Patients: Such as those in a hypermetabolic state due to severe trauma, burns, sepsis, etc.